Diabetic Cardiomyopathy

J Diabetes. 2014 Oct 28. doi: 10.1111/1753-0407.12239. [ Identification of a definite diabetic cardiomyopathy in type 2 diabetes by comprehensive echocardiographic evaluation A cross-sectional comparison with non-diabetic weight-matched controls.

Ofstad AP , Urheim S, Dalen H, Orvik E, Birkeland KI, Gullestad L, Fagerland MW, Johansen OE, Aakhus S.

Objetivo
Abstract Subclinical left
ventricular (LV) dysfunction is prevalent in type 2 diabetes (T2DM). As obesity has been proposed as one causal factor in the disease process, this could bias the reported prevalences. We wanted to characterize echocardiographic LV dysfunction in obese T2DM subjects as compared to non-diabetic obese controls.

METHODS:

One hundred patients with T2DM without clinical signs of heart failure (29% females, mean±SD age 58.4±10.5 yrs, BMI 30.1±5.5 kg/me blood pressure (BP) 141±18/83±9 mmHg) and 100 non-diabetic controls (29% females) matched for age (58.6±10.5yrs), BMI (29.8±4.0 kg/2m ) and systolic BP (140±14 mmHg) underwent echocardiography and color tissue Doppler imaging (TDI). Diastolic function was evaluated conventional Doppler recordings and early (e') and late (a') myocardial velocities. The ratio between early transmitral filling (E) and the corresponding myocardial tissue velocity (e') served as an index of LV filling pressure.

RESULTS:

T2DM patients had more concentric hypertrophy with a relative wallthickness of 0.42±0.07 vs controls 0.38±0.07, p < 0.001. The T2DM group had signs of diastolic dysfunction with lower E/A ratio (0.91±0.27 vs. 1.12±0.38, p<0.001), deceleration time (195±49 vs 242±72 ms, p<0.001), e' (5.7±2.0 vs. 6.6±1.8 cm/s, p=0.001) and a' (6.5±2.0 vs. 7.6±1.5 cm/s, p<0.001) compared to the controls, and higher E/e' (13.3±4.7 vs. 11.1±3.5, p<0.001). Thus, there were indications of pseudo normalization and increased filling pressure in T2DM group, whereas the controls had evidence for relaxation abnormalities without elevated filling pressure.

Conclusion

Compared to a non-
diabetic obese group, more advanced subclinical impairment of diastolic function was seen in T2DM.

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