Consumo de fibratos y elevación de creatinina en ancianos

There was no apparent effect on the need for dialysis or on mortality, however. Dr. Garg and colleagues think this may be "because increases in creatinine levels from fibrate use do not represent true kidney injury." Indeed, they note that fibrates may have long-term renal benefits.

That said, they conclude: "Until we have a better understanding of the underlying mechanism by which fibrates increase serum creatinine level and its long-term renal effects, we believe that, when fibrates are prescribed to older patients, it would be prudent to start the prescription at a low dosage and arrange for close monitoring of renal function, as has been done in clinical trials."

SOURCE: http://bit.ly/IyES9C