Nitrates and Other Nitric Oxide Donors in Cardiology - Current Positioning and Perspectives
Nitrates and Other Nitric Oxide Donors in Cardiology - Current Positioning and Perspectives:
Abstract
Nitric oxide donors have been commonly used in the therapy of cardiovascular disease for more than 150 years. In spite of
this longevity and the popularity of their use, it appears somewhat paradoxical that there is no current consistent use among
cardiologists, as to both their indications and their optimal mode of administration. In part this results from their contradictory
pharmacodynamics: when given acutely, their effectiveness is undisputable; however, their long-term efficacy is potentially
limited by the development of tolerance and the induction of endothelial dysfunction, which may have negative prognostic implications.
This review reports recent biochemical and pathophysiological acquisitions, re-examines the role of nitrates and other nitric
oxide donors in cardiovascular medicine, comparing and commenting on international guidelines; and highlights areas of uncertainty,
where more clinical research with these drugs would still be warranted.
this longevity and the popularity of their use, it appears somewhat paradoxical that there is no current consistent use among
cardiologists, as to both their indications and their optimal mode of administration. In part this results from their contradictory
pharmacodynamics: when given acutely, their effectiveness is undisputable; however, their long-term efficacy is potentially
limited by the development of tolerance and the induction of endothelial dysfunction, which may have negative prognostic implications.
This review reports recent biochemical and pathophysiological acquisitions, re-examines the role of nitrates and other nitric
oxide donors in cardiovascular medicine, comparing and commenting on international guidelines; and highlights areas of uncertainty,
where more clinical research with these drugs would still be warranted.
- Content Type Journal Article
- Category Review Article
- Pages 1-15
- DOI 10.1007/s10557-011-6354-0
- Authors
- Francesco Iachini Bellisarii, Institute of Cardiology, “G. d’Annunzio” University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy
- Francesco Radico, Institute of Cardiology, “G. d’Annunzio” University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy
- Francesca Muscente, Institute of Cardiology, “G. d’Annunzio” University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy
- John Horowitz, Department of Medicine, The Queen Elizabeth Hospital, Adelaide, Australia
- Raffaele De Caterina, Institute of Cardiology, “G. d’Annunzio” University - Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy
- Journal Cardiovascular Drugs and Therapy
- Online ISSN 1573-7241
- Print ISSN 0920-3206
posted by Dr Rafael R Morales Zamora Cardiologo @ 11:22 a.m.
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