Gouty arthritis: Understanding the disease state and management options in primary care

Gouty arthritis: Understanding the disease state and management options in primary care:

Abstract  

Acute gouty arthritis is an inflammatory response triggered by the release of monosodium urate crystal deposits into the joint
space. The disease is associated with debilitating clinical symptoms and functional impairments as well as adverse economic
and quality-of-life burdens. Because gouty arthritis is typically diagnosed and managed in the primary care setting, clinicians
require a thorough knowledge of the presenting clinical features, risk factors, differential diagnoses, and treatment options
for appropriate management. Although generally effective, the use of currently available therapies to control gouty arthritis
is challenging because many medications used to treat comorbidities can exacerbate gouty arthritis and because current agents
are associated with a number of adverse events, contraindications, or both. Based on an understanding of the underlying inflammatory
pathogenesis of gouty arthritis, several new agents are being developed that may provide improved efficacy.

• Content Type Journal Article
• Category Review
• Pages 748-760
• DOI 10.1007/s12325-011-0058-5
• Authors
  
  
  • Prashanth Sunkureddi, The University of Texas Medical Branch (UTMB), 2060 Space Park Drive, Suite 208, Nassau Bay, TX 77058, USA
  
  

• Journal Advances in Therapy
• Online ISSN 1865-8652
• Print ISSN 0741-238X




• Journal Volume Volume 28




• Journal Issue Volume 28, Number 9